研究業績

2013年以前の業績は旧サイトをご覧ください。

2024年

• 服部 佑佳子. ショウジョウバエと共生微生物叢. 生物工学会誌 バイオミディア. 第102巻第4号, 181 (2024)
• Misato Kurio, Yuma Tsukasa, Tadashi Uemura, and Tadao Usui. Refinement of a technique for collecting and evaluating the osmolality of haemolymph from Drosophila larvae. Journal of Experimental Biology, in press.
• Yun Zhang, Hsin-Ho Sung, Anna B. Ziegler, Ying-Chieh Wu, Ricardo Viais, Carlos Sánchez-Huertas, Lukas Kilo, Fikret-Gürkan Agrican, Ying-Ju Cheng, Kousuke Mouri, Tadashi Uemura, Jens Lüders, Cheng-Ting Chien and Gaia Tavosanis. Augmin complex activity fine-tunes dendrite morphology through non-centrosomal microtubule nucleation in vivo. Journal of Cell Science, in press. https://doi.org/10.1242/jcs.261512 (2024)
• Masanori Arita, Bernd Pulverer, Tadashi Uemura, Chisako Sakuma, Shigeo Hayashi. Publishing in the Open Access and Open Science era. Genes to Cells. Feb 13. doi: 10.1111/gtc.13100. (2024)

2023年

• Ayumi Mure, Yuki Sugiura, Rae Maeda, Kohei Honda, Nozomu Sakurai, Yuuki Takahashi, Masayoshi Watada, Toshihiko Katoh, Aina Gotoh, Yasuhiro Gotoh, Itsuki Taniguchi, Keiji Nakamura, Tetsuya Hayashi, Takane Katayama, Tadashi Uemura, Yukako Hattori. Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild. eLife, 12:RP90148. https://doi.org/10.7554/eLife.90148.3. (2023).
  自然界で動物の成長を支える共生微生物叢―中心的な役割を担う共生酵母・細菌の同定―
• Toshiyuki Harumoto. Self-stabilization mechanism encoded by a bacterial toxin facilitates reproductive parasitism. Current Biology, Sep 25;33(18):4021-4029.e6. DOI: https://doi.org/10.1016/j.cub.2023.08.032. (2023)
  オス殺しのコストパフォーマンスが高いわけ―共生細菌の毒素は自己安定化のしくみをもつ―
• Ki-Hyeon Seong, Tadashi Uemura and Siu Kang. Road to sexual maturity: Behavioral event schedule from eclosion to first mating in each sex of Drosophila melanogaster. iScience, Jul 28;26(9):107502. DOI: https://doi.org/10.1016/j.isci.2023.107502. (2023).
• Shunta Sakaguchi, Sonoko Mizuno, Yasushi Okochi, Chiharu Tanegashima, Osamu Nishimura, Tadashi Uemura, Mitsutaka Kadota, Honda Naoki, Takefumi Kondo.* Single-cell transcriptome atlas of Drosophila gastrula 2.0. Cell Reports, Jul 3;112707. DOI: https://doi.org/10.1016/j.celrep.2023.112707. (2023).
• Kai Li, Yuma Tsukasa, Misato Kurio, Kaho Maeta, Akimitsu Tsumadori, Shumpei Baba, Risa Nishimura, Akira Murakami, Koun Onodera, Takako Morimoto, Tadashi Uemura, Tadao Usui.* Belly roll, a GPI-anchored Ly6 protein, regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons. eLife, Jun 13;12:e83856. DOI: https://doi.org/10.7554/eLife.83856. (2023).
  痛みを抑制するタンパク質を発見！―痛覚多様性からのアプローチ―
• Taiichi Tsuyama, Yusaku Hayashi, Hanae Komai, Kohei Shimono, and Tadashi Uemura. Dynamic de novo adipose tissue development during metamorphosis in Drosophila melanogaster. Development, May 15;150(10):dev200815. DOI: https://doi-org.kyoto-u.idm.oclc.org/10.1242/dev.200815. (2023).
  ショウジョウバエを用いて脂肪組織が発達する仕組みを解明 ―前駆細胞の遠距離移動と増殖を可視化し、制御遺伝子を同定
• Daisuke Kageyama, Toshiyuki Harumoto, Keisuke Nagamine, Akiko Fujiwara, Takafumi N. Sugimoto, Akiya Jouraku, Masaru Tamura, Takehiro K. Katoh & Masayoshi Watada. A male-killing gene encoded by a symbiotic virus of Drosophila. Nature communications, Mar 13;14(1):1357. DOI:https://doi.org/10.1038/s41467-023-37145-0. (2023).
• Yasutetsu Kanaoka, Koun Onodera, Kaori Watanabe, Yusaku Hayashi, Tadao Usui, Tadashi Uemura,* Yukako Hattori.* Inter-organ Wingless/Ror/Akt signaling regulates nutrient-dependent hyperarborization of somatosensory neurons. eLife, Jan 17;12:e79461. DOI: https://doi.org/10.7554/eLife.79461. (2023).
  低栄養なのに神経細胞は成長する？―栄養に応じて分岐を制御する神経−筋肉連関―
  Fruit flies grow brainy on a poor diet

2022年

• Shuangyu Luo, Kanji Furuya, Kimiya Matsuda, Yuma Tsukasa, Tadao Usui, Tadashi Uemura. E-cadherin-dependent coordinated epithelial rotation on a two-dimensional discoidal pattern. Genes to Cells, Dec 23. DOI: https://doi.org/10.1111/gtc.13001 (2022)
• Goshi Ogita, Takefumi Kondo, Keisuke Ikawa, Tadashi Uemura, Shuji Ishihara, Kaoru Sugimura. Image-based parameter inference for epithelial mechanics. PLOS Compu Biol., Jun 23;18(6):e1010209 (2022).
• Maiko Abe, Takumi Kamiyama, Yasushi Izumi, Qingyin Qian, Yuma Yoshihashi, Yousuke Degawa, Kaori Watanabe, Yukako Hattori, Tadashi Uemura, Niwa, Ryusuke.* Shortened lifespan induced by a high-glucose diet is associated with intestinal immune dysfunction in Drosophila sechellia. J Exp Biol., Nov 1;225(21):jeb244423.(2022).

2021年

• Yasushi Okochi†, Shunta Sakaguchi†, Ken Nakae, Takefumi Kondo* and Honda Naoki*. Model-based prediction of spatial gene expression via generative linear mapping. Nature Communications, Jun 17; 12(1):3731 † Equal contribution * Corresponding authors (2021).
• 上村匡、渡辺佳織、服部佑佳子。「モデル生物と非モデル生物との対比で迫る栄養環境への適応機構」 生化学 特集「食・栄養から健康を拓く生化学」93, 67-77 (2021).

2020年

• Masayoshi Watada, Yusaku Hayashi, Kaori Watanabe, Shoko Mizutani, Ayumi Mure, Yukako Hattori, Tadashi Uemura. Divergence of Drosophila species: longevity and reproduction under different nutrient balances. Genes to Cells, Sep;25(9):626-636. *Corresponding authors (2020).
• 渡辺佳織、上村匡、服部佑佳子。「種間の栄養環境への適応能力の差を生む炭水化物応答機構」 実験医学2月号（2020). https://www.yodosha.co.jp/jikkenigaku/book/9784758125284/index.html

2019年

• Kaori Watanabe, Yasutetsu Kanaoka, Shoko Mizutani, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura, and Yukako Hattori. Interspecies comparative analyses reveal distinct carbohydrate-responsive systems among Drosophila species. Cell Reports, Volume 28, ISSUE 10, P2594-2607.e7, September 03, 2019 * Corresponding authors (2019).
  栄養に柔軟に適応し成長するシステムの解明 －種間の適応能力の差を生む炭水化物応答機構－
  Why fruit flies eat practically anything
  
• Yasutetsu Kanaoka†, Henrik Skibbe†, Yusaku Hayashi, *Tadashi Uemura and *Yukako Hattori. DeTerm: Software for automatic detection of neuronal dendritic branch terminals via an artificial neural network. Genes to Cells, Jul;24(7):464-472
  †Equal contribution
  *Corresponding authors (2019).

2018年

• 碓井理夫、個体の逃避行動を制御するメカニズム：感覚ニューロンのイニシアティブ。 生化学 90巻6号 834-838 (2018).
• Koji Kikuchi, Akira Nakamura, Masaki Arata, Dongbo Shi, Mami Nakagawa, Tsubasa Tanaka, Tadashi Uemura, Toshihiko Fujimori, Akira Kikuchi, Akiyoshi Uezu, Yasuhisa Sakamoto, and Hiroyuki Nakanishi. Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling. EMBO reports, e45471 (2018).
• 碓井理夫（責任著者）、服部佑佳子、上村 匡。 「樹状突起パターンを調節する細胞外因性および神経活動に依存したメカニズム」、　森泰生・尾藤晴彦編著 「脳神経化学」化学同人、第20章 (2018).

2017年

• Koun Onodera, Shumpei Baba, Akira Murakami, Tadashi Uemura, and Tadao Usui. Small conductance Ca²⁺-activated K⁺ channels induce the firing pause periods during the activation of Drosophila nociceptive neurons. eLife, 6:e29754 (2017).
  神経活動の「波のうねり」が痛みの情報を担うしくみを解明
• Masaki Arata, Kaoru Sugimura, and Tadashi Uemura. Difference in Dachsous levels between migrating cells coordinates the direction of collective cell migration. Developmental Cell, 42: 479-498 (2017).
  細胞集団が移動方向を調節して組織を形作る、新しい仕組みを発見
• Taiichi Tsuyama, Asako Tsubouchi, Tadao Usui, Hiromi Imamura, and Tadashi Uemura. Mitochondrial dysfunction induces dendritic loss via eIF2α phosphorylation. Journal of Cell Biology, 216(3): 815-834 (2017).
  ミトコンドリア関連神経疾患において特定の種類の神経細胞が強く影響を受けるメカニズムを提唱
• Kaori Watanabe, Yuki Furumizo, Tadao Usui, *Yukako Hattori, and *Tadashi Uemura. Nutrient-dependent dendrite arborization of somatosensory neurons. Genes to Cells, Jan; 22(1): 105-114 (2017).

2016年

• Hiroshi Koyama, Dongbo Shi, Makoto Suzuki, Naoto Ueno, Tadashi Uemura, Toshihiko Fujimori. Mechanical regulation of three-dimensional epithelial fold pattern formation in the mouse oviduct. The Biophysical Journal, 111(3):650-665 (2016).
• Dongbo Shi, Masaki Arata, Tadao Usui, Toshihiko Fujimori and Tadashi Uemura. Seven-pass transmembrane cadherin CELSRs, and Fat4 and Dchs1 cadherins: from planar cell polarity to three-dimensional organ architecture. Chapter 10 (p251-275) in “The Cadherin Superfamily: Key Regulators of Animal Development and Physiology” (S. Suzuki and S. Hirano eds, Springer)
• Dongbo Shi, Fumiko Usami, Kouji Komatsu, Sanae Oka, Takaya Abe, Tadashi Uemura, Toshihiko Fujimori. Dynamics of planar cell polarity protein Vangl2 in the mouse oviduct epithelium. Mechanisms of Development, 141:78-89 (2016).
• 服部佑佳子、モデル生物から非モデル生物へ。 実験医学 34巻4号 633 (2016).
• Shin-Ichiro Terada, Daisuke Matsubara, Koun Onodera, Masanori Matsuzaki, *Tadashi Uemura, and *Tadao Usui (*: Corresponding authors). Neuronal Processing of Noxious Thermal Stimuli Mediated by Dendritic Ca²⁺ Influx in Drosophila Somatosensory Neurons. eLife, 5:e12959 (2016).
  危機回避行動を感覚ニューロンが調節するしくみを解明 －痛覚神経細胞の発火パターンが回避行動を選択している

2015年

• 石東博、藤森俊彦、上村匡。平面内細胞極性シグナル。生体の科学増大号 66巻5号、特集「細胞シグナル操作法」(2015).

2014年

• 服部佑佳子、上村匡。神経細胞の個性を生み出す転写調節ネットワーク。 生体の科学 増大号 65巻5号、特集「生命動態システム科学」(2014).
• Dongbo Shi, Kouji Komatsu, Mayumi Hirao, Yayoi Toyooka, Hiroshi Koyama, Fadel Tissir, Andre M Goffinet, Tadashi Uemura, and Toshihiko Fujimori. Celsr1 is required for multilevel polarities formation of mouse oviduct. Development, 141, 4558-4568 (2014).
  卵を一方向に運ぶ器官を作る仕組みを発見
• Kohei Shimono, Kazuto Fujishima, Takafumi Nomura, Masayoshi Ohashi, Tadao Usui, Mineko Kengaku, Atsushi Toyoda, and Tadashi Uemura. An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size. Scientific Reports, Mar 19;4:4415 (2014).
  体の大きさに合わせて神経細胞の大きさを制御するしくみを解明
• Yuta Takayama, Reina E. Itoh, Taiichi Tsuyama, and Tadashi Uemura. Age-dependent deterioration of locomotion in Drosophila melanogaster deficient in the homolog of Amyotrophic Lateral Sclerosis 2. Genes to Cells, Jun;19(6):464-77 (2014).
• Kousuke Mouri, Yutaro Nishino, Masaki Arata, Dongbo Shi, Shin-ya Horiuchi, and Tadashi Uemura. A novel planar polarity gene pepsinogen-like regulates wingless expression in a posttranscriptional manner, Developmental Dynamics, Jun;243(6):791-9 (2014).